Hormonal effects on the cardiovascular system.
Pathophysiological mechanisms of chronic renal failure: basic-clinical studies.
Cardiovascular remodeling, vascular calcification. Role of immune system
cardiovascular damage in hypertension and heart failure.
Problem Description: Cardiovascular disease is highly prevalent in the population and represent the main cause of death. Hypertension and chronic renal failure are important risk factors in the development of cardiovascular disease with a complex evolution. Cardiovascular damage is modulated by several hormones that act on cells of the cardiovascular system. The research at our laboratory addresses the pathophysiological mechanisms involved in the development of cardiovascular disease in hypertension and chronic renal failure, with particular attention to the actions of hormones. We combine basic studies in experimental models (cell, tissue, experimental animals) and clinical studies. We use a pathophysiologic approach, with molecular tools, cellular biology tools and methodology for clinical studies. Our clinical studies are oriented to explore pathophysiological mechanisms and new therapeutic interventions.
Ongoing projects funded: FONDECYT 1090223. Artrioesclerosis mechanisms in chronic renal failure: regulation of phosphate transporters and transdifferentiation of smooth muscle by aldosterone and leptin (from 2009 to 2012). 15010006 FONDAP Project CEMC, (2002-2012). Project P04/030F. Millennium Nucleus on Immunology and Immunotherapy, (2009-2011).